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KMID : 1007420140120030228
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Mood and Emotion
2014 Volume.12 No. 3 p.228 ~ p.233
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The Longitudinal Course and Cycling Pattern of Korean Patients with Bipolar I Disorder
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Lee Hwang-Bin
Yim Seon-Jin
Yoo Nam-Hee
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Abstract
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Objectives: We evaluated the clinical characteristics, longitudinal courses and the cycle-length patterns of patients with bipolar I disorder.
Methods: We assessed one hundred twenty patients (n=120) with bipolar I disorder by retrospective medical records review. Single manic, continuous and rapid cycling courses were excluded.
Results: There were some differences in longitudinal course of patients with bipolar I disorder according to gender and the index episode. Manic onsets were more frequent in men (53.4%), whereas depressive onsets were more frequent in women (51.6%). The age of onset in mixed or hypomanic onset group (16.0±0 yrs, 20.0±2.4 yrs) were younger than in manic (24.6±7.3 yrs) or depressive (25.7±7.5 yrs) onset group. Initial manic episode was more related to later mania, whereas initial depressive episode was more related to later depression. Consistent findings of progressive shortening of cycle were not observed.
Conclusion: The type of the index episode appears to have gender-related clinical differences. Age of onset is different according to the index episode. The index episode seems to influence the predominant polarity of the bipolar I disorder in each individual patient. The cycle-length patterns were not progressive cycling over time, nor gradual lengthening in later episodes in this study.
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KEYWORD
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Bipolar I disorder, Longitudinal course, Cycling pattern
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